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Check-in
16Mar2026Select date
Check-out
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Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

221 East Main Street, Vermillion, South Dakota, United States, SD 57069
-
Near the National Music Museum
Perfect
9.6
/10
5.0
/5

Located just 1.4 km from USD Luther Center, the 3-star Main Street Inn Vermillion is merely 500 metres from the multi - purpose DakotaDome Stadium. There is also complimentary private parking.

Location

You'll need 53-minute drive to Sioux Gateway airport. This Vermillion bed & breakfast offers location within 20 minutes' walk of the W. H. Over Museum.

The National Music Museum is located not far from the Main Street Inn Vermillion.

Cottage Avenue bus stop, offering a direct link to the city attractions and main places, is 900 m from the hotel.

Rooms

The rooms overlook the city and feature a flat-screen TV with satellite channels along with coffee/tea making facilities. An air conditioner are featured for guests' comfort. Providing a separate toilet and a shower, the bathrooms are also appointed with hair dryers and free toiletries.

Eat & Drink

Red Steakhouse is located next to Main Street Inn and serves American dishes, nearly a 5-minute walk away.

Must-do experiences

  • Stroll through the charming Main Street for local shops and cafes.
  • Visit the National Music Museum for a unique musical history.
  • Try the famous buffalo wings at The Jade Garden-local favorite!
  • Discover the hidden beauty of the Riverfront Trail for a scenic walk.
  • Check out the annual Coyote Days festival for local art and music.
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Select your room type

Main Street Inn offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Single Room Bathroom
2 persons
325 sq. feet 
1 King-size bed
Shower
Coffee machine
Single Room
2 persons
325 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe Single Room
2 persons
400 sq. feet 
1 King-size bed
Shower
Coffee machine
Double Room
2 persons
455 sq. feet 
2 King Size Beds
Shower
Coffee machine
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Price and Room Availability Calendar

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Facilities

Main Street Inn offers amenities for your comfortable stay and unforgettable experiences
Facilities: Perfect
9.3/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • No pets allowed

Children

  • Cots

Room features

  • Air conditioning
  • Heating
  • Tea and coffee facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Main Street Inn Location

221 East Main Street, Vermillion, South Dakota, United States, SD 57069
Map view
221 East Main Street, Vermillion, South Dakota, United States, SD 57069
Nearby
414 E Clark St The University of South Dakota
Shrine to Music Museum
1800 ft
Restaurants
Leo's Sports Bar and Grill
1500 ft
11 Market St
Getting around
City Centre
Vermillion3 min  ·  700 ft
Airports
Sioux Gateway Airport (SUX)110 min  ·  45.4 mi
Stronsay Airport (soy)153 min  ·  63.1 mi
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Property information and rules
Check-in
from 15:00-21:00
Check-out
from 08:00-11:00
Internet
Wireless internet is available in for free.
Breakfast
The hotel Main Street Inn provides visitors with a free full breakfast. 
Pets
Pets are not allowed.

Reviews and Ratings

Feedback about Main Street Inn from previous guests about their experience.
Review score
Based on 13 verified reviews
9.8/10
Perfect
100%
Recommend
Cleanliness
9.3/10
Comfort
9.3/10
Facilities
9.3/10
Location
9.3/10
Staff
9.3/10
Value for money
9.3/10
Guest reviews
based on 8 reviews
9.6/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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Check-in
16Mar2026Select date
Check-out
17Mar2026Select date
Rooms and Guests2 Guests, 1 Room