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From125US$ /night
Check-in
16Mar2026Select date
Check-out
17Mar2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

201 North Main Street, Hannibal, Missouri, United States, 63401
-
Steps from Bluff City Theater
Perfect
9.1
/10
4.5
/5

Situated about 5 minutes' walk from Mark Twain Boyhood Home and Museum, the 4-star Main Street Bed & Breakfast Hannibal offers a nightclub and a golf course.

Location

Nestled 2.6 km from Park United Methodist Church, the bed & breakfast is 2.7 km from Immanuel Baptist Church. This Hannibal hotel is within easy reach of Clemens Field and 45 km from Quincy Regional airport.

The Main Street Hannibal lies approximately 10 minutes' drive from the Sawyer's Creek.

Rooms

The rooms comprise a seating area complete with an iron and an air conditioner, as well as a flat-screen TV with satellite channels and streaming services. They are furnished with sound-proof windows, and also come with coffee and tea making equipment. Bathrooms include a spa bathtub, a separate toilet, and a shower, along with comforts such as a hair dryer and bath sheets.

Eat & Drink

Breakfast is provided with granola, muffins, and yogurt. Serving American meals, Becky Thatcher's Diner lies just near the Main Street.

Must-do experiences

  • Start your day with a homemade breakfast at the B&B's dining area.
  • Visit the Mark Twain Boyhood Home for a glimpse into history.
  • Savor the famous toasted ravioli at The Brick Oven Restaurant.
  • Take a scenic stroll along the Mississippi River waterfront park.
  • Explore the unique finds at the Hannibal Farmers Market on Saturdays.
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Select your room type

Main Street Bed & Breakfast offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Deluxe Queen Suite
2 persons
400 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
445 sq. feet 
1 King-size bed
Shower
Coffee machine

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

Main Street Bed & Breakfast offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.9/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • VIP check-in/ -out
  • Express check-in/ -out
  • Concierge desk
  • No pets allowed
  • Security
  • Adults only
  • Smoke detectors
  • Fire extinguishers
  • Key access

Sports & Fitness

  • Canoeing
  • Hiking
  • Cycling
  • Bowling
  • Golf course
  • Fishing

Services

  • Valet parking
  • Housekeeping
  • Tours/Ticket assistance

Dining

  • In-room breakfast
  • Special diet menus

Spa & Leisure

  • Aqua park
  • Live entertainment
  • Night club
  • BBQ facilities
  • Jacuzzi

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Garden furniture
  • Tea and coffee facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Main Street Bed & Breakfast Location

201 North Main Street, Hannibal, Missouri, United States, 63401
Map view
201 North Main Street, Hannibal, Missouri, United States, 63401
Nearby
Museum
Mark Twain Boyhood Home and Museum
1400 ft
Bridge
Mark Twain Memorial Lighthouse
1400 ft
Hannibal
Tom and Huck's Statue
1400 ft
Museum
Jim's Journey
1400 ft
211 Hill St
Haunted House on Hill Street Wax Museum
800 ft
Hannibal
Becky Thatcher's House
1400 ft
114 S 3rd St
Karlocks Kars and Pop Culture Museum
1100 ft
320 N 3rd St
Big River Train Town
1400 ft
600 Butler St
Molly Brown Museum and Home
1400 ft
Library
Hannibal Free Public Library
1800 ft
Park
Glascock's Landing
1400 ft
162-198 North St
Tom Sawyer and Huck Finn Statue
1100 ft
320 Broadway
Hannibal Parks & Recreation
1100 ft
Museum
Hannibal History Museum
1400 ft
600 Butler St
Molly Brown Birthplace
1400 ft
Store
Bluff City Theatre
1400 ft
Restaurants
The Brick Oven
100 ft
207 Center Street
Java Jive
200 ft
211 N Main St
Finn's Food and Spirits
200 ft
214 N Main St
Chocolaterie Stam
300 ft
103 N Main St
Riverside Restaurant
600 ft
111 Bird St
Mark Twain Dinette
1100 ft
400 N 3rd St
Getting around
City Centre
Hannibal5 min  ·  1400 ft
Airports
Quincy Regional Airport (UIN)68 min  ·  27.8 mi
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Property information and rules
Check-in
from 14:00-20:00
Check-out
from 06:00-11:00
Guest Parking
Private parking is possible on site for free.
Internet
Wireless internet is available in for free.
Breakfast
At the hotel Main Street Bed & Breakfast guests are invited to a full breakfast served for free. 
Pets
Pets are not allowed.

Reviews and Ratings

Feedback about Main Street Bed & Breakfast from previous guests about their experience.
Review score
Based on 73 verified reviews
8.9/10
Great
95%
Recommend
Breakfast
7.5/10
Cleanliness
9.4/10
Comfort
9.2/10
Facilities
8.9/10
Free Wi-Fi
8.5/10
Location
9.3/10
Paid Wi-Fi
10.0/10
Staff
9.4/10
Value for money
8.9/10
Guest reviews
based on 151 reviews
9.1/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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Check-in
16Mar2026Select date
Check-out
17Mar2026Select date
Rooms and Guests2 Guests, 1 Room