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From108US$ /night
Check-in
29Jan2026Select date
Check-out
30Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

109 Matthews Lane, Sikeston, Missouri, United States, 63801
-
Near the Sikeston Depot Museum & Gallery
Great
8.1
8.0
/10
3.7
3.6
/5

Situated within 10 minutes' drive of the Malco Sikeston Cinema and Grill and 4.9 km from Saint Francis Xavier Church, the 3-star heritage Comfort Inn & Suites Sikeston I-55 features a private art gallery. Guests will enjoy an indoor pool while staying in this Sikeston hotel a short way from the Mississippi River.

Location

You'll need 34-minute drive to Cape Girardeau Regional airport. There is the Sikeston Depot Museum & Gallery 4.7 km from the Comfort Inn & Suites.

Rooms

Some bathrooms have a separate toilet, along with a hair dryer.

Eat & Drink

McDonald's serves various kinds of American dishes only a few steps from the hotel.

Leisure & Business

Also, at the accommodation, guests can take advantage of a golf club provided onsite.

Must-do experiences

  • Taste the famous fried catfish at Lambert's Café, just down the road.
  • Visit the Sikeston Depot Museum for local history and unique exhibits.
  • Stroll through the Sikeston Farmer's Market on Saturday mornings.
  • Enjoy a show at the Bootheel Youth Museum for family-friendly fun.
  • Explore the picturesque gardens at the Sikeston Nature Center.
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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
King Room Non-Smoking
2 persons
360 sq. feet 
1 King-size bed
King Suite Non-Smoking
2 persons
360 sq. feet 
1 King-size bed
Queen Room Two Queen Beds Non-Smoking
2 persons
360 sq. feet 
2 King Size Beds
King Room Accessible or Non-Smoking
2 persons
1 King-size bed
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Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • Pets allowed

Children

  • Cots

Spa & Leisure

  • Indoor swimming pool

Bathroom

  • Washing machine

Media

  • AM/FM alarm clock
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Location

109 Matthews Lane, Sikeston, Missouri, United States, 63801
Map view
109 Matthews Lane, Sikeston, Missouri, United States, 63801
Restaurants
El Nopalito Grill
900 ft
2600 E Malone Ave
Getting around
City Centre
Sikeston8 min  ·  3.0 mi
Airports
Cape Girardeau Regional Airport (CGI)65 min  ·  26.7 mi
Barkley Regional Airport (PAH)135 min  ·  55.8 mi
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Property information and rules
Check-in
from 14:00-23:59
Check-out
until 11 am
Guest Parking
Private parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are allowed on request.
Year renovated:
2007
Number of rooms:
64
Check-in
29Jan2026Select date
Check-out
30Jan2026Select date
Rooms and Guests2 Guests, 1 Room
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