21C Museum Hotel St Louis Saint Louis Exterior photo21C Museum Hotel St Louis Saint Louis Interior photo21C Museum Hotel St Louis Saint Louis Interior photo
Book on our site
up to 10% cheaper
than Booking.com
Check rooms and rates
From234US$ /night
Check-in
03May2026Select date
Check-out
04May2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

1528 Locust Street, Saint Louis, Missouri, United States, 63103
-
Close to the Gateway Arch
Great
8.5
8.8
/10
4.2
4.1
/5

Positioned approximately 25 minutes' walk from the national park "Gateway Arch" and a mere 0.7 km from Aloe Plaza, the contemporary 21C Museum Hotel St Louis Saint Louis provides an event space for a variety of uses. Located within reach of the City Museum, this 4-star smoke-free hotel features an indoor pool for guests to relax in.

Location

The hotel is situated in the very heart of Saint Louis 400 m from the World Aquarium. The 21C Museum Hotel St Louis Saint Louis gives access to Sacrifice, which is merely a 7-minute walk away.

A family vacation to Saint Louis will become more exciting if you visit The St. Louis Wheel lying in proximity to the property.

This hotel is 400 m from Washington at 16th Street bus stop and within a 1-km distance of Union train station in Saint Louis.

Rooms

There are 137 rooms at 21C Museum Hotel St Louis, each of them has an iron and air conditioning, as well as entertainment amenities such as a flat-screen TV with satellite channels and pay-per-view channels.

Eat & Drink

The à la carte Idol Wolf restaurant offers a wide assortment of Spanish dishes. Guests can relax and have a snack in the lounge bar.

Leisure & Business

The 21C Museum Hotel St Louis offers such facilities as a personal trainer and yoga instruction, along with a steam room and a Jacuzzi. Guests have the option of attending fitness classes at a fitness centre available on site. Also, a spa salon will be a perfect addition to your stay. Business travellers are welcome to use meeting rooms offered on site.

Must-do experiences

  • Visit Citygarden for amazing art sculptures and a relaxing stroll.
  • Try Ted Drewes Frozen Custard for a classic St. Louis dessert treat.
  • Experience the stunning views from the Gateway Arch's observation deck.
  • Explore the eclectic shops at the Delmar Loop, a vibrant local district.
  • Don't miss the free admission at the Missouri History Museum!
View all

Select your room type

21C Museum Hotel St Louis offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Deluxe King Room
2 persons
315 sq. feet 
1 King-size bed
Shower
Heating
Deluxe King Suite Roll Shower Accessible
2 persons
510 sq. feet 
1 King-size bed
Shower
Heating
Loft Two Queen Beds
2 persons
435 sq. feet 
2 King Size Beds
Shower
Heating
Deluxe King Room Accessible
2 persons
315 sq. feet 
1 King-size bed
Shower
Heating
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

21C Museum Hotel St Louis offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.7/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • 24-hour security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Coffee shop
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Billiard tables
  • Yoga class

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities

Children

  • Cots
  • Board games
  • Game room

Facilities for people with disabilities

  • Toilet for disabled

Spa & Leisure

  • Indoor swimming pool
  • Leisure/ TV room
  • Spa & wellness centre
  • Steam room
  • Jacuzzi
  • Massage

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • Direct dial telephone
  • AM/FM alarm clock
Show more

21C Museum Hotel St Louis Location

1528 Locust Street, Saint Louis, Missouri, United States, 63103
Map view
1528 Locust Street, Saint Louis, Missouri, United States, 63103
Nearby
Museum
City Museum
1800 ft
Museum
Campbell House Museum
300 ft
Church
Christ Church Cathedral
1500 ft
1315 Chestnut St
Soldiers Memorial Military Museum
2000 ft
Aquarium
World Aquarium
1400 ft
Church
Centenary United Methodist Church
700 ft
Night club
The Boom Boom Room
1000 ft
13th and Locust
Lucas Garden Park
1200 ft
Restaurants
The Last Kitchen
1200 ft
1501 Washington Ave Inside The Last Hotel
Red Oak Biscuits
1100 ft
1330 Washington Ave
Nara Cafe and Hookah Lounge
1100 ft
1326 Washington Ave
Flannery's
1300 ft
1324 Washington Ave
Rooftop Cafe at City Museum
1400 ft
701 N 15th St Fl 11
Lucas Park Grille
1500 ft
1234 Washington Avenue
Rosalita's Cantina
1600 ft
1235 Washington Avenue
Blondie's Coffee
1500 ft
1301 Washington Ave
Imo's Pizza
1400 ft
1828 Washington Ave
Papa John's Pizza
2100 ft
201 N Tucker Blvd Ste E
Bootleggin' BBQ
2200 ft
1933 Washington Ave
Getting around
City Centre
Saint Louis8 min  ·  2000 ft
Airports
Lambert (STL)33 min  ·  13.5 mi
MidAmerica St. Louis/Scott Air Force Base (BLV)62 min  ·  25.4 mi
Train
Union Station9 min  ·  2300 ft
Bus
Bus stop3 min  ·  700 ft
Interested in Nearby Hotel Rates?
Live prices. No outdated rates
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in for free.
Pets
Pets are allowed on request.
Number of floors:
10
Number of rooms:
137

Reviews and Ratings

Feedback about 21C Museum Hotel St Louis from previous guests about their experience.
Review score
Based on 1102 verified reviews
8.5/10
Great
83%
Recommend
Breakfast
6.6/10
Cleanliness
8.9/10
Comfort
8.7/10
Facilities
8.7/10
Free Wi-Fi
7.8/10
Location
8.6/10
Paid Wi-Fi
5.9/10
Staff
8.6/10
Value for money
8.1/10
Guest reviews
based on 1024 reviews
8.5/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
Check-in
03May2026Select date
Check-out
04May2026Select date
Rooms and Guests2 Guests, 1 Room