21C Museum Hotel Louisville Exterior photo The photo shows a sunny street scene in a city, featuring a prominent golden statue of a muscular male figure, likely a depiction of the Greek god Hercules or a similar mythological character. The statue stands on a light-colored pedestal in the midd21C Museum Hotel Louisville Exterior photo21C Museum Hotel Louisville Exterior photo

21C Museum Hotel Louisville, Louisville

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Check rooms and rates
From$167 /night
Check-in
18Jun
Check-out
19Jun
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, 40202
-
Steps from the Waterfront
Great
8.9
9.3
/10
4.6
4.5
/5

The 5-star boutique-style 21C Museum Hotel Louisville is situated approximately 5 minutes on foot from the world-class Frazier History Museum and boasts a sauna, spa therapy, and spa services. Featuring a banquet hall, this Louisville hotel is located within a 2-km distance of the historic boarding Thomas Edison House.

Location

The hotel is nearly 10 minutes on foot from the Muhammad Ali Center, just around the corner from the Kentucky Science Center. You can visit the Revelry Boutique Gallery that is 2.1 km from the 21C Museum Hotel Louisville.

For sport fans the accommodation offers access to the Kentucky International Convention Center, which is only an 11-minute walk away.

Main / 7th bus stop, offering a direct link to the city attractions and main places, is close to this Louisville hotel.

Rooms

21C Museum Hotel Louisville features 96 rooms equipped with a flat-screen TV with satellite channels as well as a mini fridge bar, tea and coffee making facilities. An air conditioner are featured for guests' comfort. You can enjoy views of the city.

Eat & Drink

Proof On Main is an in-house American restaurant, serving American dishes. Drinks are available at the 24-hour bar. You can visit a quick bites situated close by and taste Italian cuisine.

Leisure & Business

At the 21C Museum Hotel, guests can also benefit from fitness classes provided at a gym. Sports lovers will enjoy bike riding and yoga. There is a business centre available for corporate travellers.

Must-do experiences

  • Sample the famous Hot Brown at the Brown Hotel, a local tradition.
  • Visit the Muhammad Ali Center for an inspiring cultural experience.
  • Explore the Big Four Bridge for stunning views of the Ohio River.
  • Don't miss the NuLu district for unique shops and art galleries.
  • Stop by the Louisville Mega Cavern for underground zip-lining fun.

Select your room type

21C Museum Hotel Louisville offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
  • Room Balcony
    2 persons
    29 sq. feet
    1 King-size bed
    Air conditioning
    Balcony
  • Deluxe King Room
    2 persons
    31 sq. feet
    1 King-size bed
    Air conditioning
    Heating
  • Corner Suite
    2 persons
    61 sq. feet
    1 King-size bed
    Air conditioning
    Bathtub
Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!
June 2026 - June 2027
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Check-in/ Check-out

Facilities

21C Museum Hotel Louisville offers amenities for your comfortable stay and unforgettable experiences
Facilities: Perfect
9.0/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

21C Museum Hotel Louisville Location

700 West Main Street, Louisville, 40202
Getting around
  • City Centre
    Louisville 23 min  ·  1.2 mi
  • Airports
    Louisville (SDF) 18 min  ·  7.4 mi
Interested in Nearby Hotel Rates?
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in the entire hotel for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel

Reviews and Ratings

Feedback about 21C Museum Hotel Louisville from previous guests about their experience.
Review score
Based on 429 verified reviews
9.0 /10
Perfect
88 %
Recommend
Breakfast
2.5/10
Cleanliness
9.2/10
Comfort
9.3/10
Facilities
9.0/10
Free WiFi
10.0/10
Location
9.4/10
Paid Wi-Fi
7.5/10
Staff
9.0/10
Value for money
8.1/10
Guest reviews
based on 1899 reviews
4.5/5
based on 184 reviews
8.9/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
Check-in
18Jun
Check-out
19Jun
Rooms and Guests2 Guests, 1 Room