21C Museum Hotel Louisville Exterior photo The photo shows a sunny street scene in a city, featuring a prominent golden statue of a muscular male figure, likely a depiction of the Greek god Hercules or a similar mythological character. The statue stands on a light-colored pedestal in the midd21C Museum Hotel Louisville Exterior photo This image is a composite shot featuring two distinct elements: a large, striking taxidermy or sculptural display of a tiger, and a blurred background showing the interior of a restaurant.

**The Focal Point (Top):**
Dominating the upper half of the 21C Museum Hotel Louisville Exterior photo This is a brightly lit, professional photograph set inside a well-stocked bar.

In the center foreground, a smiling woman with medium brown hair is posing behind the bar counter. She is wearing a sheer, black long-sleeved top and is looking directly
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From209US$ /night
Check-in
03May2026Select date
Check-out
04May2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Waterfront
Great
8.8
9.3
/10
4.6
4.5
/5

The 5-star boutique-style 21C Museum Hotel Louisville is situated approximately 5 minutes on foot from the world-class Frazier History Museum and boasts a sauna, spa therapy, and spa services. Featuring a banquet hall, this Louisville hotel is located within a 2-km distance of the historic boarding Thomas Edison House.

Location

The hotel is nearly 10 minutes on foot from the Muhammad Ali Center, just around the corner from the Kentucky Science Center. You can visit the Revelry Boutique Gallery that is 2.1 km from the 21C Museum Hotel Louisville.

For sport fans the accommodation offers access to the Kentucky International Convention Center, which is only an 11-minute walk away.

Main / 7th bus stop, offering a direct link to the city attractions and main places, is close to this Louisville hotel.

Rooms

21C Museum Hotel Louisville features 96 rooms equipped with a flat-screen TV with satellite channels as well as a mini fridge bar, tea and coffee making facilities. An air conditioner are featured for guests' comfort. You can enjoy views of the city.

Eat & Drink

Proof On Main is an in-house American restaurant, serving American dishes. Drinks are available at the 24-hour bar. You can visit a quick bites situated close by and taste Italian cuisine.

Leisure & Business

At the 21C Museum Hotel, guests can also benefit from fitness classes provided at a gym. Sports lovers will enjoy bike riding and yoga. There is a business centre available for corporate travellers.

Must-do experiences

  • Sample the famous Hot Brown at the Brown Hotel, a local tradition.
  • Visit the Muhammad Ali Center for an inspiring cultural experience.
  • Explore the Big Four Bridge for stunning views of the Ohio River.
  • Don't miss the NuLu district for unique shops and art galleries.
  • Stop by the Louisville Mega Cavern for underground zip-lining fun.
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Select your room type

21C Museum Hotel Louisville offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
315 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
335 sq. feet 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
660 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
500 sq. feet 
1 King-size bed
Shower
Coffee machine
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Facilities

21C Museum Hotel Louisville offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.8/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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21C Museum Hotel Louisville Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
600 ft
Museum
Muhammad Ali Center
1000 ft
Museum
Kentucky Science Center
500 ft
Museum
The Frazier History Museum
900 ft
Museum
Kentucky Museum of Art and Craft
300 ft
528 W Main St
Evan Williams Bourbon Experience
700 ft
Gallery
Flame Run Glass Studio and Gallery
1000 ft
500 W Main St
The Belvedere
900 ft
Night club
Jimmy Can't Dance
300 ft
801 W Main St
Michter's Fort Nelson Distillery
500 ft
Library
Sons of the American Revolution Genealogical Research Library
700 ft
120 N 10th St
Kentucky Peerless Distilling Co
1600 ft
401 W River Rd
Belle of Louisville Riverboats
2000 ft
Restaurants
Proof On Main
100 ft
702 West Main Street
Mussel & Burger Bar Downtown
200 ft
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
400 ft
614 W Main St
Atlantic No. 5
600 ft
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
600 ft
445 E Market St
Vincenzo's Italian Restaurant
1500 ft
150 S 5th St
Jockey Silks Bourbon Bar
1600 ft
140 N 4th St 2nd Floor - West Tower
Dish on Market
1600 ft
434 W Market St
Quiznos
1800 ft
223 S 5th St
Swizzle Dinner & Drinks
1800 ft
140 N Fourth St 25th Floor
Cafe Magnolia
2000 ft
140 N 4th St Galt House Hotel
Getting around
City Centre
Louisville23 min  ·  1.2 mi
Airports
Louisville (SDF)18 min  ·  7.4 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel

Reviews and Ratings

Feedback about 21C Museum Hotel Louisville from previous guests about their experience.
Review score
Based on 251 verified reviews
9.1/10
Perfect
90%
Recommend
Breakfast
2.5/10
Cleanliness
9.0/10
Comfort
9.2/10
Facilities
8.8/10
Free Wi-Fi
10.0/10
Location
9.4/10
Paid Wi-Fi
7.5/10
Staff
8.9/10
Value for money
8.2/10
Guest reviews
based on 1899 reviews
4.5/5
based on 183 reviews
8.8/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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Check-in
03May2026Select date
Check-out
04May2026Select date
Rooms and Guests2 Guests, 1 Room